Choukroun Platelet-Rich Fibrin as an Autogenous Graft Biomaterial in Preimplant Surgery:
Authors: Jonathan du Toit & Howard Gluckman
Results of a Preliminary Randomized, Human Histomorphometric, Split-Mouth Study
An investigation of the pre-implant application of Choukroun PRF, including histologic findings in healed and healing bone cases.
This study aimed to test the null hypothesis that platelet-rich fibrin (PRF), as an immediate post-extraction graft material, produces bone that is histomorphometrically no different than bone derived from healing without intervention.
The authors compared split-mouth human bone biopsy specimens derived from PRF with bone that had healed without intervention. Eight human bone biopsies were successfully harvested from four patients. The mean ± standard deviation (SD) percent of newly formed osteoid was 9.9% ± 5.9% for specimens derived from PRF, and 4% ± 2.1% for specimens derived from the control sites (P = .089; 95% confidence interval [CI] 4.5–18.1 and 1.6–6.6, respectively). Mean ± SD percent of new mineralized bone was 40.8% ± 10.3% for the PRF specimens and 43.9% ± 16.8% for the control specimens (P = .72, 95% CI, 33.4–55.6 and 19.3–55.5, respectively). Newly formed bone to fibrovascular tissue ratios for specimens in the PRF and control groups were 51%:49% and 48%:52%, respectively. Within the limitations of this study, the null hypothesis could not be rejected. Bone derived from PRF histologically did not differ from bone that healed without intervention.
The International Journal of Periodontics & Restorative Dentistry,
Volume 36, 2016